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GABBR1 antibody (AA 651-750)

GABBR1 Reactivity: Human, Rat ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN669756
  • Target See all GABBR1 Antibodies
    GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
    Binding Specificity
    • 17
    • 14
    • 12
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 651-750
    Reactivity
    • 56
    • 52
    • 42
    • 9
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 47
    • 20
    • 3
    • 2
    Rabbit
    Clonality
    • 52
    • 20
    Polyclonal
    Conjugate
    • 47
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GABBR1 antibody is un-conjugated
    Application
    • 62
    • 21
    • 19
    • 17
    • 15
    • 13
    • 13
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Dog,Cow,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GABABR1
    Isotype
    IgG
    Top Product
    Discover our top product GABBR1 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
    Alternative Name
    GABABR1 (GABBR1 Products)
    Synonyms
    GABABR1 antibody, GABBR1-3 antibody, GB1 antibody, GPRC3A antibody, dJ271M21.1.1 antibody, dJ271M21.1.2 antibody, gabbr1 antibody, GABBR1 antibody, GABA(B)R1 antibody, GABAB1 antibody, GABAbR1 antibody, bM573K1.1 antibody, gamma-aminobutyric acid type B receptor subunit 1 antibody, gamma-aminobutyric acid (GABA) B receptor, 1a antibody, gamma-aminobutyric acid (GABA) B receptor, 1 antibody, GABBR1 antibody, gabbr1a antibody, gabbr1 antibody, Gabbr1 antibody
    Background

    Synonyms: GB1, GPRC3A, GABABR1, GABBR1-3, dJ271M21.1.1, dJ271M21.1.2, Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABBR1

    Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

    Gene ID
    2550
    UniProt
    Q9UBS5
    Pathways
    Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process
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