tau antibody (tau Protein) (Atto 565)

Details for Product anti-tau Protein Antibody No. ABIN6698758
Antigen
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • tau
  • PHF-tau
  • microtubule associated protein tau
  • MAPT
Reactivity
Human, Mouse (Murine)
1079
866
738
62
16
16
10
9
5
4
3
2
Host
Rabbit
1001
96
5
4
Clonality
Polyclonal
Conjugate
This tau antibody is conjugated to Atto 565
48
40
40
40
40
40
40
30
29
22
22
22
22
22
7
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
3
2
2
1
1
Application
ELISA, Western Blotting (WB)
713
367
288
197
124
94
87
80
27
19
12
12
12
9
3
3
1
Options
Immunogen Synthetic peptide from the full length of Human Tau
Specificity Detects ~45.8kda.
Purification Protein A Purified
Antigen
Alternative Name Tau
Background Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
Gene ID 4137
UniProt P10636
Application Notes
  • WB (1:1000)
  • optimal dilutions for assays should be determined by the user.
  • optimal dilutions for assays should be determined by the user.
Comment

A 1:1000 dilution of ABIN6698758 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
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