ESCO1 antibody (Establishment of Cohesion 1 Homolog 1 (S. Cerevisiae))

Details for Product anti-ESCO1 Antibody No. ABIN6710254
Target
Reactivity
Human, Mouse, Rat
17
4
2
2
2
1
1
Host
Rabbit
15
2
Clonality
Polyclonal
Conjugate
This ESCO1 antibody is un-conjugated
1
1
1
1
1
1
1
Application
Western Blotting (WB)
11
3
2
1
1
Options
Immunogen A synthetic peptide corresponding to residues in Human ESCO1.
Specificity ESCO1 polyclonal antibody detects endogenous levels of ESCO1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity > 95% (by SDS-PAGE)
Target
Alternative Name ESCO1 (ESCO1 Antibody Abstract)
Background EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar to ẟ- and β-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
Molecular Weight ~ 95 kDa
UniProt Q5FWF5
Application Notes WB: 1:500~1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in PBS with 0.1 %  Sodium Azide, 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term.