NEIL2 antibody (Nei Endonuclease VIII-Like 2 (E. Coli))

Details for Product anti-NEIL2 Antibody No. ABIN6710590
Antigen
Reactivity
Human, Rat (Rattus)
45
13
8
5
4
2
2
2
1
1
Host
Rabbit
37
8
Clonality
Polyclonal
Conjugate
This NEIL2 antibody is un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
40
19
3
2
2
1
1
1
Options
Immunogen A synthetic peptide corresponding to residues in Human NEIL2
Specificity NEIL2 polyclonal antibody detects endogenous levels of NEIL2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity > 95% (by SDS-PAGE)
Antigen
Alternative Name NEIL2 (NEIL2 Antibody Abstract)
Background NEIL1, NEIL2 and NEIL3, also known as Endonuclease VIII-like 1,2 and 3 or DNA-(apurinic or apyrimidinic site) lyase NEIL 1, 2 and 3, are nuclear proteins involved in the repair of DNA damaged by oxidation. The NEIL proteins belong to the FPG family of proteins. They act as DNA glycosylases that can recognize and remove damaged bases, leaving an abasic site. NEIL3, however, lacks the proline residue at the N-terminus which acts as the active site residue found in NEIL1 and NEIL2. NEIL1 is a ubiquitiously expressed protein that is up-regulated during S-phase. NEIL2 is expressed primarily in testis, heart, skeletal muscle, placenta, brain, kidney and liver while NEIL3 is detected primarily in thymus and testis.
Molecular Weight ~ 37 kDa
UniProt Q969S2
Pathways DNA Damage Repair
Application Notes WB: 1:500~1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term.