TBC1D2 antibody (TBC1 Domain Family, Member 2) Primary Antibody
TBC1D2 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN6710765
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- Human, Mouse, Rat
- This TBC1D2 antibody is un-conjugated
- Western Blotting (WB)
- TBC1D2 polyclonal antibody detects endogenous levels of TBC1D2 protein.
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- > 95% (by SDS-PAGE)
- A synthetic peptide corresponding to residues in Human TBC1D2.
- Application Notes
- WB: 1:500~1:1000
- For Research Use only
- 1 mg/mL
- 1 mg/mL in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze-thaw cycles.
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term.
- Alternative Name
- TBC1D2 (TBC1D2 Antibody Abstract)
- PARIS-1, PARIS1, TBC1D2A, A630005A06Rik, BC022630, Gm1037, TBC1 domain family member 2, TBC1 domain family, member 2, TBC1D2, Tbc1d2
- GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.
- Molecular Weight
- ~ 105 kDa
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