NOM1 (nucleolar protein with MIF4G domain 1), also known as SGD1, is an 860 amino acid protein that localizes to the nucleolus, where it plays a role in targeting PP1. A member of the CWC22 family, NOM1 is expressed in skeletal muscle and heart, and contains one MI domain and a MIF4G domain. The MIF4G typically functions in protein translation and may act as a binding site for members of the eIF4A family. As such, NOM1 is thought to interact with eIF4AI, eIF4AII and eIF4AIII. The gene encoding NOM1 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5 % of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.