BAX antibody (BCL2-Associated X Protein) (N-Term)

Details for Product anti-BAX Antibody No. ABIN6711677
Antigen
  • BAX-ALPHA
  • bax-A
  • xBax
  • xlbax
  • BAX
  • bax
  • fj16e01
  • wu:fc50b10
  • wu:fj16e01
  • BCL2L4
  • BCL2 associated X, apoptosis regulator
  • BCL2-associated X protein L homeolog
  • BCL2-associated X protein
  • bcl2-associated X protein, a
  • BAX
  • bax.L
  • bax
  • baxa
  • Bax
Alternatives
anti-Human BAX antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term
84
43
31
21
21
18
15
12
11
10
9
9
8
8
7
7
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
500
230
209
90
42
29
27
20
10
6
5
4
4
3
3
2
2
1
1
1
1
1
1
1
Host
Rabbit
341
187
5
2
Clonality
Polyclonal
Conjugate
This BAX antibody is un-conjugated
17
13
12
11
10
10
6
6
6
6
6
6
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
405
201
185
147
99
88
84
42
39
22
20
13
9
6
5
5
2
1
1
1
1
1
1
Options
Immunogen Synthetic peptide, corresponding to the N-terminus of Human Bax.
Specificity Bax (S4) polyclonal antibody detects endogenous levels of Bax protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others BAX products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Bax (BAX Antibody Abstract)
Background The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
Molecular Weight ~ 21 kDa
UniProt Q07812
Pathways p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded protein response
Application Notes WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term.
Supplier Images
Western Blotting (WB) image for anti-BCL2-Associated X Protein (BAX) (N-Term) antibody (ABIN6711677) Western blot (WB) analysis of Bax (S4) polyclonal antibody at 1:500 dilution Lane1:A5...
Product cited in: Zhang, Zhang, Zhao, Wang, Ji, Zhang: "(S)-ZJM-289 preconditioning induces a late phase protection against nervous injury induced by transient cerebral ischemia and oxygen-glucose deprivation." in: Neurotoxicity research, Vol. 26, Issue 1, pp. 16-31, 2015 (PubMed).

Zhang, Xu, Xu, Zhang, Wu, Wang, Zhang, Yang, Cai, Yan, Mao, Zhu, Shao, Qian, Xu: "SALL4, a novel marker for human gastric carcinogenesis and metastasis." in: Oncogene, Vol. 33, Issue 48, pp. 5491-500, 2015 (PubMed).

Chen, Xu, Song: "IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R/PI3K/AKT signaling and secretion of VEGF." in: Molecular and cellular biochemistry, Vol. 386, Issue 1-2, pp. 167-75, 2014 (PubMed).

Zhang, Kuang, Zhao, Wu, Zhang, Lei, Xia, Chen, Wang, Ma, Li, Yang, Wang: "Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 699-706, 2014 (PubMed).

Chen, Pang, Yang, Meng, Liu, Zhou, Zhang, Xu, Gao, Chen, Tao, Wang, Yang: "Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction." in: PLoS ONE, Vol. 8, Issue 11, pp. e79418, 2014 (PubMed).

Xiao, Tang, Wang, Yang, Li, Kuang, Song: "ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-κB pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 32, Issue 6, pp. 1587-99, 2014 (PubMed).

Tan, Lai, Liu, Long, Chen, Zha, Wang, Chen, Ji, Lai: "ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 11, pp. 2632-42, 2014 (PubMed).

Liang, Xie, Jiang, Jin, Li, Liu: "The Combined effects of hematoporphyrin monomethyl ether-SDT and doxorubicin on the proliferation of QBC939 cell lines." in: Ultrasound in medicine & biology, Vol. 39, Issue 1, pp. 146-60, 2013 (PubMed).

Zheng, Lu, Ma, Zhang, Qiu, Wang: "Osthole ameliorates renal ischemia-reperfusion injury in rats." in: The Journal of surgical research, Vol. 183, Issue 1, pp. 347-54, 2013 (PubMed).

Zhao, Zhu, Qin, Tao, Li, Cheng, Li, Cao, Meng, Ju, Shao, Hua, Gu, Yin: "Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP." in: Biochemical and biophysical research communications, Vol. 432, Issue 2, pp. 320-5, 2013 (PubMed).

Kong, Ren, Jia, Wang, Zhang, Zhang, Chen, Cao: "Effects of nicorandil in neuroprotective activation of PI3K/AKT pathways in a cellular model of Alzheimer's disease." in: European neurology, Vol. 70, Issue 3-4, pp. 233-41, 2013 (PubMed).

Gu, Zhang, Li, Zhou, Feng, Ding, Chi, Zhang, Guo, Wang, Zhou, Yao, Hu: "Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways." in: Virology journal, Vol. 8, pp. 530, 2012 (PubMed).

Yuan, He-Huang, Hu, Li-Quan, Hong-Jiang, Huang: "Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model." in: Regulatory peptides, Vol. 179, Issue 1-3, pp. 39-42, 2012 (PubMed).

Joo, Lee, Hwang: "Inhibition of cytokine-induced β cell apoptosis via laccase and its therapeutic advantages for insulin-dependent diabetes mellitus, type 1 diabetes." in: Biological & pharmaceutical bulletin, Vol. 33, Issue 11, pp. 1854-60, 2011 (PubMed).

Yang, Ling, Zhang, Zhao, Tang, Ji, Zhang: "ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways." in: Biochemical and biophysical research communications, Vol. 409, Issue 4, pp. 752-7, 2011 (PubMed).

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