tau antibody (tau Protein) (AA 221-270)

Details for Product anti-tau Protein Antibody No. ABIN6711924
Antigen
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • tau
  • PHF-tau
  • microtubule associated protein tau
  • MAPT
Epitope
AA 221-270
67
51
47
43
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36
32
28
27
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26
23
22
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18
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12
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2
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2
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2
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2
2
1
1
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1
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1
1
1
1
1
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1
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1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
1075
840
759
62
16
15
10
9
5
4
3
2
Host
Rabbit
1043
49
5
5
Clonality
Polyclonal
Conjugate
This tau antibody is un-conjugated
46
40
40
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40
28
27
22
22
22
22
22
5
5
5
3
3
3
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3
3
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2
2
1
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1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
652
288
287
174
88
82
39
32
27
12
12
12
9
3
3
1
1
Options
Immunogen Synthetic peptide, corresponding to amino acids 221-270 of Human Tau.
Specificity Tau (V256) polyclonal antibody detects endogenous levels of Tau protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity > 95% (by SDS-PAGE)
Antigen
Alternative Name Tau
Background Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity.
Molecular Weight 50 to 80 kDa
UniProt P10636
Application Notes WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term.
Supplier Images
Western Blotting (WB) image for anti-tau Protein (AA 221-270) antibody (ABIN6711924) Western blot (WB) analysis of Tau (V256) polyclonal antibody at 1:500 dilution Lane1:...
Product cited in: Yang, Ma, Liu, Lu, Hu, Yu: "Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 35, Issue 5, pp. 741-51, 2015 (PubMed).

Xie, Wang, Lu, Pan, Chen, Liao: "UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices." in: Journal of molecular neuroscience : MN, Vol. 53, Issue 1, pp. 59-68, 2014 (PubMed).

Peng, He, Tang, Tao, Chen, Gao, Zhang, He, Dai, Zhu, Lv, Zhang, Qiao, Zhao, Gao, Zhu: "Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24834-44, 2010 (PubMed).

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