MVP antibody (AA 2-259) (DyLight 550)

Catalog No. ABIN7354538

This Rabbit Polyclonal antibody specifically detects MVP in FACS. It exhibits reactivity toward Human.

Quick Overview for MVP antibody (AA 2-259) (DyLight 550) (ABIN7354538)

Target: MVP (Major Vault Protein (MVP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MVP antibody is conjugated to DyLight 550

Application: Flow Cytometry (FACS)

Product Details anti-MVP Antibody (DyLight 550)

Binding Specificity: AA 2-259

Purpose: Anti-Human MVP DyLight® 550 conjugated Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human MVP DyLight® 550 conjugated Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human MVP recombinant protein (Position: A2-H259).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: MVP major vault protein". 2. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996). "Major vault protein LRP-related multidrug resistance". European Journal of Cancer. 32A (6): 979-84.

Comment:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for MVP

Target: MVP (Major Vault Protein (MVP))

Alternative Name: MVP

Background:

Synonyms: Major vault protein, MVP, Lung resistance-related protein, MVP, LRP

Tissue Specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Background: Major vault protein is a protein that in humans is encoded by the MVP gene. This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Molecular Weight: 39 kDa

Gene ID: 9961

UniProt: Q14764