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CYP2C19 antibody

CYP2C19 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6719471
  • Target See all CYP2C19 Antibodies
    CYP2C19 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 (CYP2C19))
    Reactivity
    • 35
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CYP2C19 antibody is un-conjugated
    Application
    • 31
    • 13
    • 13
    • 13
    • 9
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Cytochrome p450 2C19/CYP2C19 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequence
    QNQQSEFTIE NLVITAADLL GAGTETT
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Cytochrome p450 2C19/CYP2C19 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence of human Cytochrome p450 2C19/CYP2C19 (QNQQSEFTIENLVITAADLLGAGTETT).
    Isotype
    IgG
    Top Product
    Discover our top product CYP2C19 Primary Antibody
  • Application Notes

    Application details: Western blot|0.1-0.5 μg/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1 μg/mL

    Comment

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    CYP2C19 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 (CYP2C19))
    Alternative Name
    CYP2C19 (CYP2C19 Products)
    Synonyms
    CPCJ antibody, CYP2C antibody, P450C2C antibody, P450IIC19 antibody, cytochrome P450 family 2 subfamily C member 19 antibody, cytochrome P450, family 2, subfamily C, polypeptide 19 antibody, cytochrome P450 2C19 antibody, CYP2C19 antibody
    Background

    Synonyms: Cytochrome P450 2C19, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19

    Background: Cytochrome P450 2C19 (abbreviated CYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

    Gene ID
    1557
    UniProt
    P33261
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