TNFSF11 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 11) (AA 270-317)

Details for Product anti-TNFSF11 Antibody No. ABIN672696, Supplier: Log in to see
Antigen
  • CD254
  • ODF
  • OPGL
  • OPTB2
  • RANKL
  • TRANCE
  • hRANKL2
  • sOdf
  • TNFSF11
  • Ly109l
  • OPG
  • Trance
  • cd254
  • odf
  • opgl
  • optb2
  • rankl
  • sodf
  • tnfsf11
  • trance
  • TNF superfamily member 11
  • TNF receptor superfamily member 11b
  • tumor necrosis factor (ligand) superfamily, member 11
  • TNF superfamily member 11 L homeolog
  • TNFSF11
  • TNFRSF11B
  • Tnfsf11
  • tnfsf11.L
Alternatives
anti-Human TNFSF11 antibody for Enzyme Immunoassay
Epitope
AA 270-317
55
15
14
12
11
11
10
8
8
8
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5
4
4
4
4
4
4
4
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3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
278
199
104
5
3
2
1
1
Host
Rabbit
215
124
36
7
1
Clonality
Polyclonal
Conjugate
This TNFSF11 antibody is un-conjugated
32
17
15
13
12
5
5
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
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2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
274
140
109
109
54
40
30
25
22
21
21
14
5
4
3
2
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human RANKL
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others TNFSF11 products on genomics-online (e.g. as negative or positive controls)
Alternative Name RANKL (TNFSF11 Antibody Abstract)
Background

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular location: Extracellular

Synonyms: ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TNFSF11

Gene ID 8600
UniProt O14788
Pathways NF-kappaB Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 270-317) antibody (ABIN672696) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti...
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 270-317) antibody (ABIN672696) Formalin-fixed and paraffin embedded mouse spleen labeled with Rabbit Anti OPGL/RANKL...
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 270-317) antibody (ABIN672696) Human raji cells probed with RANKL Polyclonal Antibody, Unconjugated (green) at 1:10...
Product cited in: Dolci, Portela, Onofre de Souza, Medeiros Fossati: "Atorvastatin-induced osteoclast inhibition reduces orthodontic relapse." in: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, Vol. 151, Issue 3, pp. 528-538, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: hemimaxilla

Zhan, Liu, Wang: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, 2017 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Yu, Gong, Lin, Wang, Liu, Li: "Denervation effectively aggravates rat experimental periodontitis." in: Journal of periodontal research, Vol. 52, Issue 6, pp. 1011-1020, 2017 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).

Chen, Fu, Ma, Wu, Li, Li, Shen, Wang: "Intermittent administration of parathyroid hormone ameliorated alveolar bone loss in experimental periodontitis in streptozotocin-induced diabetic rats." in: Archives of oral biology, Vol. 83, pp. 76-84, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: left maxillae

Chen, Xue, Shen, Mu, Fu: "Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway." in: International journal of molecular medicine, Vol. 37, Issue 2, pp. 329-38, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).

He, Wang, Wang, Tian, Jiang, Ren, Qiu, Fu: "Effect of glucocorticoids on osteoclast function in a mouse model of bone necrosis." in: Molecular medicine reports, Vol. 14, Issue 2, pp. 1054-60, 2016 (PubMed). (Sample species: Mouse (Murine)).

Zhang, Chen, Wei, Liu, Lei, Bai: "Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway." in: Chemico-biological interactions, Vol. 256, pp. 188-97, 2016 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: proximal femoral tissues or primary osteoblasts

Xiao, Hu, Li, Li: "Bone fracture healing is delayed in splenectomic rats." in: Life sciences, Vol. 173, pp. 55-61, 2016 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: bone

Zhang, Liu, Li, Bai: "Mycobacterium tuberculosis 10-kDa co-chaperonin regulates the expression levels of receptor activator of nuclear factor-?B ligand and osteoprotegerin in human osteoblasts." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 919-924, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Ota, Urakawa, Kozawa, Ikuta, Hamada, Tsukushi, Shimoyama, Ishiguro, Nishida: "Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis." in: Tumour biology, Vol. 36, Issue 7, pp. 5361-7, 2015 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).

Yu, Lv, Zhang, Zhang, Xiao, Li: "Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats." in: Journal of molecular histology, Vol. 46, Issue 2, pp. 195-203, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Bone

Li, Wu, Ma, Hao, Chen, Fu, Chen, Wang: "Oral administration of 5-hydroxytryptophan aggravated periodontitis-induced alveolar bone loss in rats." in: Archives of oral biology, Vol. 60, Issue 5, pp. 789-98, 2015 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).

Sun, Wang, Fu, Wang, Bi: "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." in: Cell biochemistry and biophysics, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).

Yang, Li, Yang, Shen, Zou, Zhu, Zhang, Yang, Li: "Efficacy and safety of echinacoside in a rat osteopenia model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 926928, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Sample: femur

Lescarbeau, Seib, Prewitz, Werner, Kaplan: "In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors." in: PLoS ONE, Vol. 7, Issue 8, pp. e40372, 2012 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

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