RSV-F antibody

Catalog No. ABIN6730990

Product Details

Target: RSV-F

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)

Purpose: Palivizumab is a humanised IgG1monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV).

Specificity: "Palivizumab is a humanised IgG1monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV)."

Characteristics: "This is a therapeutic antibody derived from Synagis and designed for research purposes.Palivizumab, the active ingredient of Synagis, is a humanised IgG1 monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV)." Palivizumab is a humanised IgG1κ monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV). This humanised monoclonal antibody is composed of human (95%) and murine (5%) antibody sequences. It has potent neutralising and fusion-inhibitory activity against both RSV subtype A and B strains.
Palivizumab serum concentrations of approximately 30 μg/ml have been shown to produce a 99% reduction in pulmonary RSV replication in the cotton rat model.

Purification: The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Synagis 100 was diluted 1:100)

Sterility: Sterile

Clone: Palivizumab

Application Details

Application Notes: Optimal dilution for a specific application should be determined by user

Comment:

Palivizumab is a recombinant humanised monoclonal antibody produced by DNA technology in mouse myeloma host cells.

Protocol: Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: The dilutant is sterile PBS pH 7.4. No preservatives added

Preservative: Without preservative

Handling Advice: open only under sterile conditions

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Expiry Date: 48 months

Target Details

Target: RSV-F

Alternative Name: RSV protein F

Molecular Weight: 64 kDa

Gene ID: 1494475

NCBI Accession: NC_001781

UniProt: O36634