RSV-F antibody

Details for Product No. ABIN6730990
Antigen
Reactivity
Human
3
Host
Mouse
3
Antibody Type
Recombinant Antibody
Clonality (Clone)
Monoclonal ()
Application
Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
1
1
1
1
1
1
1
1
Options
Purpose Palivizumab is a humanised IgG1monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV).
Clone Palivizumab
Specificity "Palivizumab is a humanised IgG1monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV)."
Characteristics "This is a therapeutic antibody derived from Synagis and designed for research purposes.Palivizumab, the active ingredient of Synagis, is a humanised IgG1 monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV)." Palivizumab is a humanised IgG1κ monoclonal antibody directed to an epitope in the A antigenic site of the fusion protein of respiratory syncytial virus (RSV). This humanised monoclonal antibody is composed of human (95%) and murine (5%) antibody sequences. It has potent neutralising and fusion-inhibitory activity against both RSV subtype A and B strains.
Palivizumab serum concentrations of approximately 30 μg/ml have been shown to produce a 99% reduction in pulmonary RSV replication in the cotton rat model.
Purification The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Synagis 100 was diluted 1:100)
Sterility Sterile
Antigen
Alternative Name RSV protein F
Molecular Weight 64 kDa
Gene ID 1494475
NCBI Accession NC_001781
UniProt O36634
Application Notes Optimal dilution for a specific application should be determined by user
Comment

Palivizumab is a recombinant humanised monoclonal antibody produced by DNA technology in mouse myeloma host cells.
Protocol Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer The dilutant is sterile PBS pH 7.4. No preservatives added
Preservative Without preservative
Handling Advice open only under sterile conditions
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Expiry Date 48 months