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TNFSF11 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 11) Primary Antibody

TNFSF11 Reactivity: Human BR, ELISA, FACS, IP, WB Host: CHO Cells Monoclonal Denosumab unconjugated
Catalog No. ABIN6730991
$360.00
Plus shipping costs $45.00
100 μL
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Delivery in 7 to 8 Business Days
  • Target
    TNFSF11
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 191
    • 146
    • 115
    • 46
    • 2
    • 1
    Human
    Host
    • 177
    • 31
    • 18
    • 9
    • 1
    CHO Cells
    Clonality
    • 194
    • 41
    Monoclonal
    Conjugate
    • 85
    • 23
    • 16
    • 12
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    This TNFSF11 antibody is un-conjugated
    Application
    • 125
    • 90
    • 78
    • 78
    • 39
    • 34
    • 29
    • 20
    • 12
    • 11
    • 11
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Purpose
    Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts.
    Specificity
    "Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts."
    Characteristics
    "This is a therapeutic antibody derived from Prolia and designed for research purposes.Denosumab, the active ingredient of Prolia, is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts."
    Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function and survival, thereby decreasing bone resorption in cortical and trabecular bone.
    Purification
    The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Prolia 60 was diluted 1:60)
    Sterility
    Sterile
    Clone
    Denosumab
  • Application Notes
    Optimal dilution for a specific application should be determined by user
    Comment

    Denosumab is a human monoclonal IgG2 antibody produced in a mammalian cell line (CHO) by recombinant DNA technology.

    Protocol
    Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The dilutant is sterile PBS pH 7.4. No preservatives added
    Preservative
    Without preservative
    Handling Advice
    open only under sterile conditions
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
    Expiry Date
    36 months
  • Target
    TNFSF11
    Alternative Name
    RANKL (TNFSF11 Antibody Abstract)
    Synonyms
    CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNFSF11, Ly109l, OPG, Trance, cd254, odf, opgl, optb2, rankl, sodf, tnfsf11, trance, TNF superfamily member 11, tumor necrosis factor (ligand) superfamily, member 11, TNF receptor superfamily member 11b, TNF superfamily member 11 L homeolog, TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
    Background
    Synonyms: CD254, ODF, OPGL, OPTB2, TRANCE, hRANKL2, sOdf, TNFSF11, Ly109l, OPG, Trance, cd254, odf, opgl, optb2, rankl, sodf, tnfsf11, trance
    Molecular Weight
    35 kDa
    Gene ID
    8600
    UniProt
    O14788
    Pathways
    NF-kappaB Signaling
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