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PD-1 antibody (Programmed Cell Death 1) Primary Antibody

PDCD1 Reactivity: Human BR, ELISA, FACS, IP, WB Host: CHO Cells Monoclonal Nivolumab (5C4-B8) unconjugated
Catalog No. ABIN6730992
$360.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 7 to 8 Business Days
  • Target
    PD-1 (PDCD1)
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 153
    • 97
    • 31
    • 5
    • 3
    • 1
    Human
    Host
    • 89
    • 59
    • 29
    • 20
    • 11
    • 11
    • 2
    • 1
    • 1
    • 1
    CHO Cells
    Clonality
    • 153
    • 70
    Monoclonal
    Conjugate
    • 114
    • 16
    • 14
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PD-1 antibody is un-conjugated
    Application
    • 128
    • 68
    • 60
    • 50
    • 49
    • 26
    • 14
    • 13
    • 13
    • 13
    • 9
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Purpose
    Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2.
    Specificity
    "Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2."
    Characteristics
    "This is a therapeutic antibody derived from Opdivo and designed for research purposes. Nivolumab, the active ingredient of Opdivo, is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2."
    Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2. The PD-1 receptor is a negative regulator of T-cell activity that has been shown to be involved in the control of T-cell immune responses. Engagement of PD-1 with the ligands PD-L1 and PD-L2, which are expressed in antigen presenting cells and may be expressed by tumours or other cells in the tumour microenvironment, results in inhibition of T-cell proliferation and cytokine secretion. Nivolumab potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands. In syngeneic mouse models, blocking PD-1 activity resulted in decreased tumour growth.
    Combined nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) mediated inhibition results in improved anti-tumour responses in metastatic melanoma. In murine syngeneic tumour models, dual blockade of PD-1 and CTLA-4 resulted in synergistic anti-tumour activity.
    Purification
    The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Opdivo 100 was diluted 1:10)
    Sterility
    Sterile
    Clone
    Nivolumab (5C4-B8)
  • Application Notes
    Optimal dilution for a specific application should be determined by user
    Comment

    Nivolumab is produced in Chinese hamster ovary cells by recombinant DNA technology

    Protocol
    Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The dilutant is sterile PBS pH 7.4. No preservatives added
    Preservative
    Without preservative
    Handling Advice
    open only under sterile conditions
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
    Expiry Date
    24 months
  • Target
    PD-1 (PDCD1)
    Alternative Name
    PD-1 (PDCD1 Antibody Abstract)
    Synonyms
    CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, Ly101, Pdc1, programmed cell death 1, PDCD1, Pdcd1
    Background
    Synonyms: CD279, PD1, SLEB2, hPD-1, hPD-l, Ly101, Pdc1
    Molecular Weight
    32 kDa
    Gene ID
    5133
    UniProt
    F5A532
    Pathways
    Cancer Immune Checkpoints
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