PD-1 antibody (Programmed Cell Death 1)

Details for Product anti-PDCD1 Antibody No. ABIN6730993
Antigen
Reactivity
Human
355
143
49
5
3
1
Host
CHO Cells
189
163
36
24
17
11
5
4
1
Antibody Type
Recombinant Antibody
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-1 antibody is un-conjugated
27
21
20
10
7
6
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
235
173
119
101
90
71
21
15
13
12
12
11
10
10
9
4
4
2
2
2
Options
Purpose Pembrolizumab is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2.
Clone Pembrolizumab
Isotype IgG4, kappa
Specificity "Pembrolizumab is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2."
Characteristics "This is a therapeutic antibody derived from Keytruda and designed for research purposes. Pembrolizumab, the active ingredient of Keytruda is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2."
KEYTRUDA is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2. The PD-1 receptor is a negative regulator of T-cell activity that has been shown to be involved in the control of T-cell immune responses. KEYTRUDA potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2, which are expressed in antigen presenting cells and may be expressed by tumours or other cells in the tumour microenvironment.
Purification The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Keytruda 100 was diluted 1:25)
Sterility Sterile
Antigen
Alternative Name PD-1 (PDCD1 Antibody Abstract)
Background Synonyms: CD279, PD1, SLEB2, hPD-1, hPD-l, Ly101, Pdc1
Molecular Weight 32 kDa
Gene ID 5133
UniProt F5A532
Pathways Cancer Immune Checkpoints
Application Notes Optimal dilution for a specific application should be determined by user
Comment

Pembrolizumab is a humanised monoclonal anti-programmed cell death-1 (PD-1) antibody(IgG4/kappa isotype with a stabilising sequence alteration in the Fc region) produced in Chinese hamster ovary cells by recombinant DNA technology

Protocol Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer The dilutant is sterile PBS pH 7.4. No preservatives added
Preservative Without preservative
Handling Advice open only under sterile conditions
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Expiry Date 24 months