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PD-1 antibody (Programmed Cell Death 1) Primary Antibody

PDCD1 Reactivity: Human BR, ELISA, FACS, IP, WB Host: CHO Cells Monoclonal Pembrolizumab unconjugated
Catalog No. ABIN6730993
$360.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 7 to 8 Business Days
  • Target
    PD-1 (PDCD1)
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 152
    • 97
    • 31
    • 5
    • 3
    • 1
    Human
    Host
    • 89
    • 59
    • 29
    • 20
    • 11
    • 11
    • 2
    • 1
    • 1
    CHO Cells
    Clonality
    • 152
    • 70
    Monoclonal
    Conjugate
    • 113
    • 16
    • 14
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PD-1 antibody is un-conjugated
    Application
    • 127
    • 67
    • 59
    • 50
    • 49
    • 26
    • 14
    • 13
    • 13
    • 13
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Purpose
    Pembrolizumab is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2.
    Specificity
    "Pembrolizumab is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2."
    Characteristics
    "This is a therapeutic antibody derived from Keytruda and designed for research purposes. Pembrolizumab, the active ingredient of Keytruda is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2."
    KEYTRUDA is a humanised monoclonal antibody which binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with ligands PD-L1 and PD-L2. The PD-1 receptor is a negative regulator of T-cell activity that has been shown to be involved in the control of T-cell immune responses. KEYTRUDA potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2, which are expressed in antigen presenting cells and may be expressed by tumours or other cells in the tumour microenvironment.
    Purification
    The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Keytruda 100 was diluted 1:25)
    Sterility
    Sterile
    Clone
    Pembrolizumab
    Isotype
    IgG4 kappa
  • Application Notes
    Optimal dilution for a specific application should be determined by user
    Comment

    Pembrolizumab is a humanised monoclonal anti-programmed cell death-1 (PD-1) antibody(IgG4/kappa isotype with a stabilising sequence alteration in the Fc region) produced in Chinese hamster ovary cells by recombinant DNA technology

    Protocol
    Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The dilutant is sterile PBS pH 7.4. No preservatives added
    Preservative
    Without preservative
    Handling Advice
    open only under sterile conditions
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
    Expiry Date
    24 months
  • Target
    PD-1 (PDCD1)
    Alternative Name
    PD-1 (PDCD1 Antibody Abstract)
    Synonyms
    CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, Ly101, Pdc1, programmed cell death 1, PDCD1, Pdcd1
    Background
    Synonyms: CD279, PD1, SLEB2, hPD-1, hPD-l, Ly101, Pdc1
    Molecular Weight
    32 kDa
    Gene ID
    5133
    UniProt
    F5A532
    Pathways
    Cancer Immune Checkpoints
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