Tumor Necrosis Factor antibody (Tumor Necrosis Factor alpha)

Details for Product anti-TNF Antibody No. ABIN6730997
Antigen
  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
  • RATTNF
  • Tnfa
  • tnf
  • TNF-a
  • TNFalpha
  • Tnfsf1a
  • TNFa
  • cTNF
  • Tnf-alpha
  • tnfa-like
  • TNF-ALPHA
  • dif
  • tnfa
  • xtnf
  • tnfsf2
  • tnf-alpha
  • Cachectin
  • tumor necrosis factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • tumor necrosis factor a (TNF superfamily, member 2)
  • TNF
  • Tnf
  • tnf
  • tnfb
  • tnf-alpha
  • LOC103694380
  • tnfa
Reactivity
Human
933
363
285
117
112
96
95
56
51
40
26
17
15
6
6
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4
3
3
3
2
2
1
1
1
1
Host
CHO Cells
675
486
78
48
10
6
6
5
2
2
2
1
Antibody Type
Recombinant Antibody
Clonality (Clone)
Monoclonal ()
Conjugate
This Tumor Necrosis Factor antibody is un-conjugated
160
71
35
27
20
11
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11
11
11
9
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7
7
3
2
2
2
2
2
2
1
Application
Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
652
617
418
389
244
126
118
87
70
69
63
59
32
26
26
19
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8
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Options
Purpose Adalimumab binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
Clone Adalimumab (D2E7)
Specificity "Adalimumab binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors."
Characteristics "This is a therapeutic antibody derived from Humira and designed for research purposes. Adalimumab, the active ingredient of Humira, binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors."
Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of0.1-0.2 nM).
Purification The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Humira 40 was diluted 1:100)
Sterility Sterile
Antigen
Alternative Name TNF-alpha (TNF Antibody Abstract)
Background Synonyms: DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin
Molecular Weight 26 kDa
Gene ID 21926
NCBI Accession NM_000594
UniProt P01375
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Application Notes Optimal dilution for a specific application should be determined by user
Comment

Adalimumab is a recombinant human monoclonal antibody expressed in Chinese Hamster Ovary cells.

Protocol Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer The dilutant is sterile PBS pH 7.4. No preservatives added
Preservative Without preservative
Handling Advice open only under sterile conditions
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Expiry Date 24 months
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