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CD38 antibody Primary Antibody

Reactivity: Human BR, ELISA, FACS, IP, WB Host: CHO Cells Monoclonal Daratumumab unconjugated
Catalog No. ABIN6731003
$360.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 7 to 8 Business Days
  • Target
    CD38
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 166
    • 62
    • 18
    • 5
    • 2
    • 1
    • 1
    Human
    Host
    • 112
    • 70
    • 35
    • 7
    • 1
    CHO Cells
    Clonality
    • 159
    • 63
    • 1
    Monoclonal
    Conjugate
    • 74
    • 19
    • 15
    • 13
    • 10
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD38 antibody is un-conjugated
    Application
    • 172
    • 52
    • 46
    • 44
    • 40
    • 35
    • 32
    • 27
    • 26
    • 26
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Purpose
    Daratumumab is an IgG1κ human monoclonal antibody (mAb) that binds to the CD38 protein expressed at a high level on the surface of multiple myeloma tumour cells, as well as other cell types and tissues at various levels.
    Specificity
    "Daratumumab is an IgG1κ human monoclonal antibody (mAb) that binds to the CD38 protein expressed at a high level on the surface of multiple myeloma tumour cells, as well as other cell types and tissues at various levels."
    Characteristics
    "This is a therapeutic antibody derived from Darzalex and designed for research purposes.Daratumumab, the active ingredient of Darzalex, is an IgG1κ human monoclonal antibody (mAb) that binds to the CD38 protein expressed at a high level on the surface of multiple myeloma tumour cells, as well as other cell types and tissues at various levels."
    Daratumumab is an IgG1κ human monoclonal antibody (mAb) that binds to the CD38 protein expressed at a high level on the surface of multiple myeloma tumour cells, as well as other cell types and tissues at various levels. CD38 protein has multiple functions such as receptor mediated adhesion, signalling and enzymatic activity.
    Daratumumab has been shown to potently inhibit the in vivo growth of CD38-expressing tumour cells. Based on in vitro studies, daratumumab may utilize multiple effector functions, resulting in immune mediated tumour cell death. These studies suggest that daratumumab can induce tumour cell lysis through complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis in malignancies expressing CD38. A subset of myeloid derived suppressor cells (CD38+MDSCs), regulatory T cells (CD38+Tregs) and B cells (CD38+Bregs) are susceptible to daratumumab mediated cell lysis.
    Daratumumab induced apoptosis in vitro after Fc mediated cross-linking. In addition, daratumumab modulated CD38 enzymatic activity, inhibiting the cyclase enzyme activity and stimulating the hydrolase activity. The significance of these in vitro effects in a clinical setting, and the implications on tumour growth, are not well-understood.
    Purification
    The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug Darzalex 100 was diluted 1:20)
    Sterility
    Sterile
    Clone
    Daratumumab
  • Application Notes
    Optimal dilution for a specific application should be determined by user
    Comment

    Daratumumab is a human monoclonal IgG1κ antibody against CD38 antigen, produced in a mammalian cell line (Chinese Hamster Ovary [CHO]) using recombinant DNA technology

    Protocol
    Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The dilutant is sterile PBS pH 7.4. No preservatives added
    Preservative
    Without preservative
    Handling Advice
    open only under sterile conditions
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
    Expiry Date
    18 months
  • Target
    CD38
    Abstract
    Antibody Abstract
    Synonyms
    T10, Cd38-rs1, cd38, ADPRC 1, cADPr hydrolase 1, CD38 molecule, CD38 antigen, CD38 molecule L homeolog, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, CD38, Cd38, cd38.L
    Background
    Synonyms: T10, Cd38-rs1, cd38, ADPRC 1, cADPr hydrolase 1
    Molecular Weight
    34 kDa
    Gene ID
    952
    UniProt
    P28907
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