Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IL-6 Receptor antibody (Interleukin 6 Receptor) Primary Antibody

IL6R Reactivity: Human BR, ELISA, FACS, IP, WB Host: CHO Cells Monoclonal Tocilizumab (rhPM-1) unconjugated
Catalog No. ABIN6731005
$360.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 7 to 8 Business Days
  • Target
    IL-6 Receptor (IL6R)
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 65
    • 17
    • 14
    Human
    Host
    • 49
    • 32
    • 7
    • 4
    • 1
    • 1
    • 1
    CHO Cells
    Clonality
    • 56
    • 38
    • 1
    Monoclonal
    Conjugate
    • 57
    • 17
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-6 Receptor antibody is un-conjugated
    Application
    • 51
    • 34
    • 26
    • 18
    • 10
    • 9
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Purpose
    Tocilizumab binds specifically to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R).
    Specificity
    "Tocilizumab binds specifically to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R)."
    Characteristics
    "This is a therapeutic antibody derived from RoActemra and designed for research purposes. Tocilizumab, the active ingredient of RoActemra, binds specifically to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R)" Tocilizumab binds specifically to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R). Tocilizumab has been shown to inhibit sIL-6R and mIL-6R-mediated signalling. IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, monocytes and fibroblasts. IL-6 is involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, induction of hepatic acute phase protein synthesis and stimulation of haemopoiesis. IL-6 has been implicated in the pathogenesis of diseases including inflammatory diseases, osteoporosis and neoplasia.
    Purification
    The commercial therapeutic mAb was diluted with sterile PBS to a final 1 mg/ml.  (original drug RoActemra 200 was diluted 1:20)
    Sterility
    Sterile
    Clone
    Tocilizumab (rhPM-1)
  • Application Notes
    Optimal dilution for a specific application should be determined by user
    Comment

    Tocilizumab humanised IgG1 monoclonal antibody against the human interleukin-6 (IL-6) receptor produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology

    Protocol
    Research-relevant quantities are available as licence-free consumable as diluted variant. Therapeutic monoclonal antibodies can be used from researchers in in vitro and in vivo experiments.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The dilutant is sterile PBS pH 7.4. No preservatives added
    Preservative
    Without preservative
    Handling Advice
    open only under sterile conditions
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
    Expiry Date
    30 months
  • Target
    IL-6 Receptor (IL6R)
    Alternative Name
    IL-6 R (IL6R Antibody Abstract)
    Synonyms
    IL6R, il-6ra, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, IL6R1, Il6ra, IL-6Ralpha, IL-6R, Il6r, interleukin 6 receptor, interleukin 6 receptor, alpha, IL6R, il6r, Il6r, Il6ra
    Background
    Synonyms: IL6R, il-6ra, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, IL6R1, Il6ra, IL-6Ralpha, IL6R, Il6r
    Molecular Weight
    52 kDa
    Gene ID
    3569
    UniProt
    P08887
    Pathways
    JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
You are here:
help Support