TRADD antibody (AA 111-230)

Catalog No. ABIN673314

Product Details anti-TRADD Antibody

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Binding Specificity: AA 111-230

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRADD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse of mouse TRADD

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TRADD antibody (ABIN673314)

Chen, Zhang, Zhang, Li, Sun: "Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling." in: Biochemical and biophysical research communications, Vol. 478, Issue 3, pp. 1304-9, (2016) (PubMed).

Target Details for TRADD

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Alternative Name: TRADD (TRADD Products)

Synonyms: TRADD antibody, Hs.89862 antibody, 9130005N23Rik antibody, AA930854 antibody, wu:fc59e02 antibody, zgc:103556 antibody, tradd antibody, TNFRSF1A associated via death domain antibody, conjugal transfer protein D antibody, TNFRSF1A-associated via death domain antibody, TNFRSF1A-associated via death domain L homeolog antibody, tnfrsf1a-associated via death domain antibody, TRADD antibody, traDd antibody, Tradd antibody, tradd.L antibody, tradd antibody

Background:

Synonyms: AA930854, 9130005N23Rik, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, Tradd

Background: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.

Gene ID: 71609

UniProt: Q3U0V2

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C