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MTDH antibody (AA 131-230)

MTDH Reactivity: Human WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN678863
  • Target See all MTDH Antibodies
    MTDH (Metadherin (MTDH))
    Binding Specificity
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 131-230
    Reactivity
    • 53
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 43
    • 8
    • 3
    Rabbit
    Clonality
    • 45
    • 9
    Polyclonal
    Conjugate
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTDH antibody is un-conjugated
    Application
    • 44
    • 14
    • 12
    • 12
    • 11
    • 11
    • 9
    • 9
    • 9
    • 5
    • 5
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AEG-1
    Isotype
    IgG
    Top Product
    Discover our top product MTDH Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhang, Li, Qian, Liu, Guo, Lin: "MTDH/AEG-1-based DNA vaccine suppresses metastasis and enhances chemosensitivity to paclitaxel in pelvic lymph node metastasis." in: Biomedicine & pharmacotherapy, Vol. 70, pp. 217-26, (2015) (PubMed).

    Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: "Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis." in: Journal of pediatric urology, Vol. 10, Issue 2, pp. 317-23, (2014) (PubMed).

    Zheng, Li, Wu, Liu, Sun, Yang, Hao, Sheng, Sun, Zhang, Long, Liang, Hu et al.: "Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune ..." in: Tumour biology, Vol. 35, Issue 5, pp. 4219-24, (2014) (PubMed).

    Guo, Chen, Xi, Chang, Zhang, Zhang: "AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues." in: Journal of biomedical research, Vol. 28, Issue 5, pp. 388-95, (2014) (PubMed).

  • Target
    MTDH (Metadherin (MTDH))
    Alternative Name
    LYRIC (MTDH Products)
    Synonyms
    MGC75963 antibody, 2610103J23Rik antibody, 3D3 antibody, 3D3/Lyric antibody, AEG-1 antibody, AV353288 antibody, D8Bwg1112e antibody, Lyric antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, metadherin antibody, mtdh antibody, MTDH antibody, Mtdh antibody
    Background

    Synonyms: 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3, Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein, MTDH

    Background: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

    Gene ID
    92140
    UniProt
    Q86UE4
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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