CITED1 antibody (AA 121-193) (HRP)

Catalog No. ABIN682552

Product Details anti-CITED1 Antibody (HRP)

Target: CITED1 (Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1))

Binding Specificity: AA 121-193

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CITED1 antibody is conjugated to HRP

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CITED1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CITED1

Target: CITED1 (Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1))

Alternative Name: CITED1 (CITED1 Products)

Synonyms: cited1 antibody, fi05d05 antibody, CITED1 antibody, MSG1 antibody, AI316840 antibody, AU019144 antibody, Msg1 antibody, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 antibody, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 antibody, similar to Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) antibody, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 antibody, cited1 antibody, CITED1 antibody, Cited1 antibody

Background:

Synonyms: MSG1, Cbp/p300-interacting transactivator 1, Melanocyte-specific protein 1, CITED1

Background: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling, stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Gene ID: 4435

UniProt: Q99966