SNAI1, SNAI2, SNAI3 (AA 188-264) antibody

Catalog No. ABIN685597

Product Details

Target: SNAI1, SNAI2, SNAI3

Binding Specificity: AA 188-264

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA

Cross-Reactivity: Human, Rabbit

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Snail

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Takahashi, Akamatsu, Yagami, Hasegawa, Ohgo, Abe, Iwata, Arima, Mizutani, Nakata, Matsunaga: "Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea." in: The Journal of dermatology, Vol. 40, Issue 9, pp. 720-5, (2013) (PubMed).

Target Details

Target: SNAI1, SNAI2, SNAI3

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, snail family transcriptional repressor 1 antibody, SNAI1 antibody

Background:

Synonyms: dJ710H13.1, Protein sna, Protein snail homolog, SLUGH2, SNA, Sna protein, SNAH, SNAI1, Snail homolog 1 Drosophila, Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, dJ710H13.1, SNAIL, SNAIL1, Protein sna, SLUG, WS2D, SLUGH, SLUGH1, SNAIL2, SMUC, SNAIL3, ZNF293, Zfp293

Background: The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression.

Molecular Weight: 29kDa

Gene ID: 6615, 6591, 333929

UniProt: Q02085, P97469, Q9QY31