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IFI16 antibody (AA 201-350)

IFI16 Reactivity: Human WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN687037
  • Target See all IFI16 Antibodies
    IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))
    Binding Specificity
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-350
    Reactivity
    • 35
    • 3
    • 1
    Human
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFI16 antibody is un-conjugated
    Application
    • 35
    • 12
    • 12
    • 12
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IFI16
    Isotype
    IgG
    Top Product
    Discover our top product IFI16 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))
    Alternative Name
    I16/MNDA (IFI16 Products)
    Synonyms
    IFNGIP1 antibody, PYHIN2 antibody, IFI16 antibody, Ifitm3l antibody, Ifitml antibody, interferon gamma inducible protein 16 antibody, interferon induced transmembrane protein 2 antibody, myeloid cell nuclear differentiation antigen-like protein antibody, interferon-activable protein 203 antibody, IFI16 antibody, Ifitm2 antibody, LOC100156073 antibody, LOC488622 antibody, Ifi16 antibody
    Background

    Synonyms: Gamma-interferon-inducible protein i16, Interferon-inducible myeloid dferentiation transcriptional activator, A730048F03, D3, D3cDNA, i-d3, I16, I16B, I204, I205, i205a, i205b, NGIP1, MGC9466, Mnda, p204, PYHIN2.

    Background: Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A, B, and C (85-95 kDa), which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells, fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus, regulation of protein expression, and ability to bind DNA, it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.

    Gene ID
    3428
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome
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