IFNA1 antibody

Catalog No. ABIN6937476

Product Details anti-IFNA1 Antibody

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Specificity: This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Purified recombinant human IFN-alpha1

Clone: Feb-52

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Flow Cytometry (0.5-1 μg/million cells), ,Immunofluorescence (0.5-1 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: Stimulated human peripheral blood mononuclear cells

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for IFNA1

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Alternative Name: IFNA1 (IFNA1 Products)

Synonyms: IFL antibody, IFN antibody, IFN-ALPHA antibody, IFN-alphaD antibody, IFNA13 antibody, IFNA@ antibody, Ifa1 antibody, IFN-ALPHA-1 antibody, IFN1@ antibody, IFNA1 antibody, IFN-alpha antibody, IFN-gamma antibody, IFNA antibody, IFNA2 antibody, IFNA6 antibody, IFN-alpha1 antibody, interferon alpha 13 antibody, interferon alpha 1 antibody, interferon, alpha 1 antibody, interferon, alpha 13 antibody, interferon antibody, interferon-alpha 1 antibody, interferon, alpha, leukocyte antibody, interferon-alpha-14 antibody, IFNA13 antibody, IFNA1 antibody, Ifna1 antibody, ifna1 antibody, IFNA3 antibody, IFN-ALPHA-14 antibody

Background: IFN alpha, IFN alpha 1/13, IFN alpha 1b, Interferon alpha 13 (IFNA13), Interferon alpha leukocyte (IFL), Interferon alpha-1/13 (IFN-alpha-1/13), Interferon alpha-D (IFN alphaD), Interferon alpha1 (IFNA1), LeIF D,Interferon alpha-1 (IFNA1)
Cellular localisation: Cytoplasmic & Extracellular (Secreted)

Molecular Weight: 16-27kDa

Gene ID: 3439

UniProt: P01562

Pathways: JAK-STAT Signaling, Hepatitis C