IFNA2 antibody

Catalog No. ABIN6937478

Product Details anti-IFNA2 Antibody

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat)

Specificity: Recognizes a protein of 16-27 kDa, identified as human interferon-II) (IFN-(II). Its epitope maps between aa112-148 of IFN-II) (total aa172). This MAb is specific for IFN-(II) and does not cross-react with IFN-(I). The site recognized by this MAb is called site I and is responsible for the antiviral and anti-proliferative activities of IFN-(II). Epitopes of N27 and N39 MAbs are different and represent a good combination of antibodies to set up an ELISA assay for the quantitation of IFN-(II) after viral infections. The IFN- family consists of 24 or more genes or pseudo-genes. IFN-II) is one of the two distinct families (I and II) of human IFN-. The -interferon are mainly produced by lymphocytes, monocytes, macrophages, and cell lines such as Namalwa and KG1 following induction by viruses, nucleic acids, and glucocorticoid hormones. They are involved in virus resistance on target cells, inhibition of cell proliferation, induction of cytokines and regulation of expression of MHC class I antigens.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Purified recombinant human IFN-alpha2

Clone: N39

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order Ab without BSA), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Stimulated human peripheral blood mononuclear cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for IFNA2

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Alternative Name: IFNA2 (IFNA2 Products)

Synonyms: IFN-alphaA antibody, IFNA antibody, IFNA2B antibody, INFA2 antibody, Ifa2 antibody, IFNA2 antibody, interferon alpha 2 antibody, interferon, alpha 2 antibody, interferon-alpha-2 antibody, interferon alpha-2 antibody, IFNA2 antibody, Ifna2 antibody, ifna2 antibody, IFN-ALPHA2 antibody, LOC102142148 antibody

Background: Alpha 2a interferon, IFN alpha, IFN-alpha-2, IFNA, IFNA2, IFNA2B, Interferon alpha 2a, Interferon alpha 2b, Interferon alpha-2, Interferon alpha-A, LeIF2, LeIFA,Interferon alpha-2 (IFNA2)
Cellular localisation: Cytoplasmic & Extracellular (Secreted)

Molecular Weight: 16-27kDa

Gene ID: 3440, 211575

UniProt: P01563

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Hepatitis C