NADPH Oxidase 4 antibody
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- Target See all NADPH Oxidase 4 (NOX4) Antibodies
- NADPH Oxidase 4 (NOX4)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NADPH Oxidase 4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Coating (Coat)
- Specificity
- The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human NOX4 protein
- Clone
- NOX4-1245
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product NOX4 Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order Ab without BSA)Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: PC-12, JAR cells. Kidney.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- NADPH Oxidase 4 (NOX4)
- Alternative Name
- NOX4 (NOX4 Products)
- Synonyms
- KOX antibody, KOX-1 antibody, RENOX antibody, AI648021 antibody, nox4 antibody, NOX4 antibody, NADPH oxidase 4 antibody, NOX4 antibody, Nox4 antibody, nox4 antibody, PTRG_09562 antibody
- Background
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Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX-1, NADPH oxidase 4, Nox4, Renal NAD(P)H-oxidase, RENOX,NOX4 / NADPH Oxidase 4
Cellular localisation: Cytoplasm and Cell Surface - Molecular Weight
- 70kDa
- Gene ID
- 50507, 371036
- UniProt
- Q9NPH5
- Pathways
- Carbohydrate Homeostasis, Smooth Muscle Cell Migration
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