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ORC1 antibody

ORC1L Reactivity: Human ELISA, Coat Host: Mouse Monoclonal 7F6-1 unconjugated
Catalog No. ABIN6938111
  • Target See all ORC1 (ORC1L) Antibodies
    ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
    Reactivity
    • 32
    • 19
    • 17
    Human
    Host
    • 27
    • 4
    • 1
    Mouse
    Clonality
    • 28
    • 4
    Monoclonal
    Conjugate
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ORC1 antibody is un-conjugated
    Application
    • 29
    • 13
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Coating (Coat)
    Specificity
    The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle, however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human ORC1 protein
    Clone
    7F6-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ORC1L Primary Antibody
  • Application Notes

    Known_Application: ELISA (For coating, order antibody without BSA)Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa cells.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
    Alternative Name
    ORC1L (ORC1L Products)
    Synonyms
    CG10667 antibody, DmORC1 antibody, DmOrc1 antibody, DmOrc1p antibody, Dmel\\CG10667 antibody, ORC antibody, ORC1 antibody, dORC1 antibody, orc1 antibody, rDmORC antibody, ORC1L antibody, HSORC1 antibody, PARC1 antibody, orc1l antibody, xorc1 antibody, AA545195 antibody, MmORC1 antibody, Orc1l antibody, Origin recognition complex subunit 1 antibody, origin recognition complex subunit 1 antibody, origin recognition complex subunit 1 L homeolog antibody, origin recognition complex, subunit 1 antibody, Orc1 antibody, ORC1 antibody, orc1.L antibody
    Background
    HSORC1, MmORC1, Origin Recognition Complex 1 (ORC1), Origin recognition complex subunit 1 (yeast homolog) like (ORC1L), Origin recognition complex subunit 1 like (S. cerevisia, Origin recognition complex subunit 1 like, PARC1, Replication control protein 1,ORC1
    Cellular localisation: Nucleus.
    Molecular Weight
    120kDa
    Gene ID
    4998, 17908
    UniProt
    Q13415
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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