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Recombinant Chromogranin A antibody

CHGA Reactivity: Human IHC, StM Host: Mouse Monoclonal rCHGA-413 unconjugated Recombinant Antibody
Catalog No. ABIN6939124
  • Target See all Chromogranin A (CHGA) Antibodies
    Chromogranin A (CHGA)
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 198
    • 73
    • 66
    • 28
    • 28
    • 15
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 106
    • 97
    • 5
    • 1
    Mouse
    Clonality
    • 124
    • 84
    Monoclonal
    Conjugate
    • 92
    • 18
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Chromogranin A antibody is un-conjugated
    Application
    • 113
    • 107
    • 69
    • 66
    • 60
    • 50
    • 32
    • 13
    • 13
    • 10
    • 10
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificity
    Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
    No Cross-Reactivity
    Rat (Rattus)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human CHGA protein.
    Clone
    RCHGA-413
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product CHGA Primary Antibody
  • Application Notes

    Positive Control: PC12 cells. Adrenal gland, bowel, thyroid, pancreas or pheochromocytoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.25-0.5 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    Chromogranin A (CHGA)
    Alternative Name
    CHGA (CHGA Products)
    Synonyms
    CGA antibody, CG-ALPHA antibody, FSHA antibody, GPHA1 antibody, GPHa antibody, HCG antibody, LHA antibody, TSHA antibody, ChrA antibody, fj05f09 antibody, si:dkey-177p2.2 antibody, wu:fj05f09 antibody, zgc:101749 antibody, zgc:56075 antibody, CHGA antibody, cgA antibody, chga antibody, chromogranin A antibody, glycoprotein hormones, alpha polypeptide antibody, uncharacterized CHGA antibody, chromogranin A S homeolog antibody, CHGA antibody, CGA antibody, Chga antibody, chga antibody, chga.S antibody
    Molecular Weight
    68-75kDa
    Gene ID
    1113
    UniProt
    P10645
    Pathways
    Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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