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PAPPA antibody (AA 351-523)

PAPPA Reactivity: Human IHC, StM Host: Mouse Monoclonal PAPPA-2716 unconjugated
Catalog No. ABIN6940249
  • Target See all PAPPA Antibodies
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Binding Specificity
    • 15
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-523
    Reactivity
    • 80
    • 23
    Human
    Host
    • 46
    • 39
    • 1
    Mouse
    Clonality
    • 47
    • 39
    Monoclonal
    Conjugate
    • 33
    • 13
    • 11
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAPPA antibody is un-conjugated
    Application
    • 48
    • 45
    • 27
    • 18
    • 13
    • 13
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificity
    Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
    Clone
    PAPPA-2716
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product PAPPA Primary Antibody
  • Application Notes

    Positive Control: Placenta.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Alternative Name
    PAPPA (PAPPA Products)
    Synonyms
    8430414N03Rik antibody, IGFBP-4ase antibody, PAG1 antibody, PAPP-A antibody, ASBABP2 antibody, DIPLA1 antibody, PAPA antibody, PAPPA1 antibody, Pappa antibody, pappalysin 1 antibody, pregnancy-associated plasma protein A antibody, PAPPA antibody, Pappa antibody, Pappa1 antibody
    Molecular Weight
    181kDa
    Gene ID
    5069
    UniProt
    Q13219
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