NPC1 antibody (Niemann-Pick Disease, Type C1)

Details for Product anti-NPC1 Antibody No. ABIN6944307
Antigen
  • im:7149020
  • wu:fb53a12
  • wu:fc29a12
  • A430089E03Rik
  • C85354
  • D18Ertd139e
  • D18Ertd723e
  • lcsd
  • nmf164
  • spm
  • NPC
  • Cdig2
  • NPC intracellular cholesterol transporter 1
  • Niemann-Pick disease, type C1
  • Niemann-Pick C1 protein
  • NPC1
  • npc1
  • LOC579887
  • Npc1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
59
16
7
Host
Rabbit
50
9
8
Clonality (Clone)
Monoclonal ()
Conjugate
This NPC1 antibody is un-conjugated
4
4
3
3
3
3
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
48
45
33
18
10
5
4
3
3
2
2
1
1
1
Options
Immunogen Synthetic peptide within human NPC1 aa 1250-1270
Clone 1B12
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others NPC1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NPC1 (NPC1 Antibody Abstract)
Background

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Acts as an endosomal entry receptor for ebolavirus.

Subcellular location: Lysosome, Endosome


Synonyms: NPC intracellular cholesterol transporter 1, Niemann Pick C1 protein, NPC1, POGZ, SLC65A1
Gene ID 4864
UniProt O15118
Application Notes WB(1:500-1000), FCM(1:50-100), IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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