PGC1 alpha + beta antibody

Details for Product No. ABIN6944540
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
27
27
27
12
12
12
Host
Rabbit
27
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
3
2
2
2
2
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
16
5
3
Options
Immunogen N terminal human PGC1 alpha
Clone 9C3
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PGC1 alpha,beta
Background

Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP/p300, and results in a large increase in transcriptional activity.


Synonyms: Peroxisome prolifeRator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, Peroxisome prolifeRator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B
Gene ID 133522
UniProt Q86YN6
Application Notes WB(1:300-1000)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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