PRKCE antibody (Protein Kinase C, epsilon)

Details for Product anti-PRKCE Antibody No. ABIN6944555
Target
Reactivity
Human, Mouse, Rat
124
91
79
6
4
4
2
1
1
1
1
Host
Rabbit
133
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PRKCE antibody is un-conjugated
14
9
6
6
5
5
5
5
5
4
4
4
2
2
2
2
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
105
61
43
26
20
12
11
11
10
10
4
4
3
1
1
Options
Immunogen C terminal human PKC epsilon
Clone 6B4
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PKC epsilon (PRKCE Antibody Abstract)
Background

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.


Synonyms: Protein kinase C epsilon type, nPKC-epsilon, PRKCE, PKCE
Gene ID 5581
UniProt Q02156
Pathways TCR Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
Application Notes WB(1:500-1000), FCM(1:50-100), IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months