DPP4 antibody (Dipeptidyl-Peptidase 4) (AA 473-588)

Details for Product anti-DPP4 Antibody No. ABIN6953148
Target
Binding Specificity
AA 473-588
31
17
16
9
9
7
6
4
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human, Rat
175
53
49
6
5
4
3
3
3
3
3
2
2
2
1
1
1
Host
Rabbit
102
97
18
9
3
Clonality
Polyclonal
Conjugate
This DPP4 antibody is un-conjugated
32
22
18
9
6
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
115
96
65
48
46
40
23
11
9
4
3
2
2
1
1
1
1
Options
Immunogen Recombinant Human Dipeptidyl peptidase 4 protein (473-588AA)
Isotype IgG
Purification Protein G purified
Purity > 95 %
Target
Alternative Name DPP4 (DPP4 Antibody Abstract)
Background Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
UniProt P27487
Pathways Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
Application Notes WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer 50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C,-80 °C
Storage Comment Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Images
Image no. 1 for anti-Dipeptidyl-Peptidase 4 (DPP4) (AA 473-588) antibody (ABIN6953148) Immunofluorescent analysis of PC-3 cells using ABIN6953148 at dilution of 1:100 and A...
Image no. 2 for anti-Dipeptidyl-Peptidase 4 (DPP4) (AA 473-588) antibody (ABIN6953148) Positive WB detected in: Rat kidney tissue All lanes: DPP4 antibody at 2.8 μg/mL Seco...
Image no. 3 for anti-Dipeptidyl-Peptidase 4 (DPP4) (AA 473-588) antibody (ABIN6953148) Immunohistochemistry of paraffin-embedded human prostate tissue using ABIN6953148 at ...
Image no. 4 for anti-Dipeptidyl-Peptidase 4 (DPP4) (AA 473-588) antibody (ABIN6953148) Immunohistochemistry of paraffin-embedded human small intestine tissue using ABIN6953...