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SSRP1 antibody (N-Term)

SSRP1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6972795
$605.00
Plus shipping costs $45.00
100 μL
Shipping to: United States
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  • Target See all SSRP1 Antibodies
    SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
    Binding Specificity
    • 9
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 62
    • 21
    • 16
    • 8
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 57
    • 4
    • 1
    Rabbit
    Clonality
    • 58
    • 4
    Polyclonal
    Conjugate
    • 32
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SSRP1 antibody is un-conjugated
    Application
    • 44
    • 22
    • 9
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    SSRP1 (Structure-Specific Recognition Protein 1) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. SSRP1 and Supt16H form a stable heterodimer and this complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. The HMG box DNA-binding domain mediates DNA-binding with both affinity and specificity for DNA damaged globally with cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. SSRP1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
    Purification
    Affinity Purified
    Immunogen
    This antibody was raised against a peptide within the N-terminal region of human SSRP1.
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
    Alternative Name
    SSRP1 (SSRP1 Products)
    Synonyms
    ATHMG, NFD, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR D, SSRP1, high mobility group, ssrp1, CG4817, Cf5, Dmel\\CG4817, DssRP, SSRP, dSSRP, dSSRP1, dSsrp, ssrp, Ssrp1, DDBDRAFT_0188842, DDBDRAFT_0216434, DDB_0188842, DDB_0216434, wu:fa11b03, wu:fd10f06, FACT, FACT80, T160, CIIDBP, C81323, Hmg1-rs1, Hmgi-rs3, Hmgox, high mobility group, FACT complex subunit Ssrp1, FACT complex subunit SSRP1, Structure specific recognition protein, structure specific recognition protein 1, transcription factor protein, structure specific recognition protein 1a, SSRP1 protein, structure specific recognition protein 1 S homeolog, HMG, CpipJ_CPIJ002953, CpipJ_CPIJ020011, CMU_019430, Tsp_07406, LOC100286423, Ssrp, ssrp1, SSRP1, ssrp1a, nfd110, ssrp1.S, Ssrp1
    Background
    SSRP1 (Structure-Specific Recognition Protein 1) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. SSRP1 and Supt16H form a stable heterodimer and this complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. The HMG box DNA-binding domain mediates DNA-binding with both affinity and specificity for DNA damaged globally with cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
    Molecular Weight
    81 kDa
    NCBI Accession
    NP_003137
    Pathways
    Chromatin Binding
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