TOPORS antibody (AA 21-120) (HRP)

Catalog No. ABIN6987710

Product Details anti-TOPORS Antibody (HRP)

Target: TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOPORS antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human p53 BP3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TOPORS

Target: TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))

Alternative Name: p53 BP3 (TOPORS Products)

Synonyms: CG15104 antibody, Dmel\\CG15104 antibody, TOPORS antibody, dTopors antibody, dtopors antibody, fi75f04 antibody, wu:fi75f04 antibody, AW105885 antibody, LUN antibody, TP53BPL antibody, p53BP3/LUN antibody, P53BP3 antibody, RP31 antibody, Topoisomerase I-interacting protein antibody, TOP1 binding arginine/serine rich protein antibody, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase antibody, topoisomerase I binding, arginine/serine-rich b antibody, topoisomerase I binding, arginine/serine-rich antibody, Topors antibody, TOPORS antibody, topors antibody, toporsb antibody

Background:

Synonyms: AW105885, E3 ubiquitin protein ligase Topors, E3 ubiquitin-protein ligase Topors, LUN, p53 binding protein 3, p53 BP3/LUN, p53-binding protein 3, p53BP3, p53BP3/LUN, Retinitis pigmentosa 31, RP31, SUMO1 protein E3 ligase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I binding arginine/serine rich, Topoisomerase I binding arginine/serine rich protein, Topoisomerase I binding protein, Topoisomerase I binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding RS protein, TOPORS, TOPRS_HUMAN, TP53BPL, Tumor protein p53 binding protein, Tumor suppressor p53 binding protein 3, Tumor suppressor p53-binding protein 3.

Background: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

Gene ID: 10210

UniProt: Q9NS56

Pathways: Maintenance of Protein Location