TNFSF15 antibody (N-Term)

Catalog No. ABIN6990418

Product Details anti-TNFSF15 Antibody

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Binding Specificity: AA 60-110, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: This polyclonal antibody will not cross-react with TL1.

Purification: TL1A Antibody is affinity chromatography purified via peptide column.

Immunogen: TL1A antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TL1A. The immunogen is located within amino acids 60 - 110 of TL1A.

Isotype: IgG

Application Details

Application Notes: TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TL1A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TL1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TL1A (TNFSF15 Products)

Synonyms: TTPAL antibody, TL1 antibody, TL1A antibody, VEGI antibody, VEGI192A antibody, Tl1 antibody, Tl1a antibody, Vegi antibody, tumor necrosis factor superfamily member 15 antibody, TNF superfamily member 15 antibody, tumor necrosis factor (ligand) superfamily, member 15 antibody, TNFSF15 antibody, Tnfsf15 antibody

Background: TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-κ,B activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).

Molecular Weight: Predicted: 28 kDa

Observed: 26 kDa

Gene ID: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy