TBC1D1 antibody (C-Term)

Catalog No. ABIN6990756

Product Details anti-TBC1D1 Antibody

Target: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: TBC1D1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TBC1D1 antibody was raised against a 22 amino acid synthetic peptide from near the carboxy terminus of human TBC1D1. The immunogen is located within the last 50 amino acids of TBC1D1.

Isotype: IgG

Application Details

Application Notes: TBC1D1 antibody can be used for detection of TBC1D1 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TBC1D1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TBC1D1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TBC1D1

Target: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Alternative Name: TBC1D1 (TBC1D1 Products)

Synonyms: TBC1D1 antibody, TBC antibody, TBC1 antibody, 1110062G02Rik antibody, AI385682 antibody, AW555803 antibody, Tbc1 antibody, mKIAA1108 antibody, TBC1 domain family member 1 antibody, TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 antibody, TBC1 domain family, member 1 antibody, TBC1D1 antibody, tbc1d1 antibody, LOC100523386 antibody, Tbc1d1 antibody

Background: TBC1D1 Antibody: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Molecular Weight: Predicted: 128 kDa

Observed: 140 kDa 

Gene ID: 23216

NCBI Accession: NP_055988

UniProt: Q86TI0