FEZ1 antibody (C-Term)

Catalog No. ABIN6990766

Product Details anti-FEZ1 Antibody

Target: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Binding Specificity: AA 270-320, C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FEZ1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: FEZ1 Antibody is affinity chromatography purified via peptide column.

Immunogen: FEZ1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1. The immunogen is located within amino acids 270 - 320 of FEZ1.

Isotype: IgG

Application Details

Application Notes: FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 0.5 - 1 μ,g/mL. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FEZ1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FEZ1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FEZ1

Target: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Alternative Name: FEZ1 (FEZ1 Products)

Synonyms: UNC-76 antibody, UNC76 antibody, wu:fj14c12 antibody, zgc:73258 antibody, fez1 antibody, xfez1 antibody, fasciculation and elongation protein zeta 1 antibody, fasciculation and elongation protein zeta 1 (zygin I) antibody, fasciculation and elongation protein zeta 1 L homeolog antibody, FEZ1 antibody, Fez1 antibody, fez1 antibody, fez1.L antibody

Background: FEZ1 Antibody: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.

Molecular Weight: Predicted: 42 kDa

Observed: 46 kDa

Gene ID: 9638

UniProt: Q99689