GRIK4 antibody (N-Term)

Catalog No. ABIN6990824

Product Details anti-GRIK4 Antibody

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Binding Specificity: AA 30-80, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: Grik4 Antibody is affinity chromatography purified via peptide column.

Immunogen: Grik4 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human Grik4. The immunogen is located within amino acids 30 - 80 of Grik4.

Isotype: IgG

Application Details

Application Notes: Grik4 antibody can be used for detection of Grik4 by Western blot at 0.5 - 2 μ,g/mL. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Grik4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Grik4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GRIK4

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Alternative Name: Grik4 (GRIK4 Products)

Synonyms: GRIK4 antibody, ka1 antibody, eaa1 antibody, EAA1 antibody, GRIK antibody, GluK4 antibody, KA1 antibody, 6330551K01Rik antibody, GluRgamma1 antibody, KA-1 antibody, glutamate receptor, ionotropic, kainate 4 antibody, glutamate ionotropic receptor kainate type subunit 4 antibody, glutamate receptor, ionotropic, kainate 4 L homeolog antibody, grik4 antibody, GRIK4 antibody, grik4.L antibody, Grik4 antibody

Background: Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.

Gene ID: 2900

UniProt: Q16099

Pathways: Synaptic Membrane