Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody will not cross-react with the zinc transporter ZIP10.
Purification
ZIP11 Antibody is affinity chromatography purified via peptide column.
Immunogen
ZIP11 antibody was raised against a 15 amino acid synthetic peptide near the center of the human ZIP11. The immunogen is located within amino acids 130 - 180 of ZIP11.
SLC39A11
Reactivity: Human, Mouse, Rat
WB, IF (p)
Host: Rabbit
Polyclonal
Alexa Fluor 750
Application Notes
ZIP11 antibody can be used for detection of ZIP11 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
ZIP11 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C,4 °C
Storage Comment
ZIP11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
SLC39A11
(Solute Carrier Family 39 (Metal Ion Transporter), Member 11 (SLC39A11))
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Background
ZIP11 Antibody: ZIP11, also known as Slc39A11, is a member of the broader ZIP family of multi-transmembrane domain metal ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Members of the ZIP family generally transport metal ions from the cell exterior or lumen of intracellular organelles into the cytoplasm, as opposed to the ZnT (SLC30) family of zinc transporters that serve to reduce intracellular zinc availability by promoting zinc efflux from cells or into intracellular vesicles. At least three isoforms of ZIP11 are known to exist.