ZFYVE26 antibody (C-Term)

Catalog No. ABIN6991064

Product Details anti-ZFYVE26 Antibody

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Binding Specificity: AA 1710-1760, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE26 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Specificity: Multiple isoforms of SPG15 are known to exist.

Purification: SPG15 Antibody is affinity chromatography purified via peptide column.

Immunogen: SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15.

Isotype: IgG

Application Details

Application Notes: SPG15 antibody can be used for detection of SPG15 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SPG15 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SPG15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ZFYVE26

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Alternative Name: SPG15 (ZFYVE26 Products)

Synonyms: wu:fc33a03 antibody, FYVE-CENT antibody, SPG15 antibody, 4930465A13 antibody, 9330197E15Rik antibody, A630028O16Rik antibody, Gm893 antibody, mKIAA0321 antibody, zinc finger, FYVE domain containing 26 antibody, zinc finger FYVE-type containing 26 antibody, zfyve26 antibody, ZFYVE26 antibody, Zfyve26 antibody

Background: SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking.

Molecular Weight: Predicted: 280 kDa

Observed: 260 kDa

Gene ID: 23503

UniProt: Q68DK2