SEC16B antibody (C-Term)

Catalog No. ABIN6991282

Product Details anti-SEC16B Antibody

Target: SEC16B (SEC16 Homolog B (SEC16B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC16B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: LZTR2 Antibody is affinity chromatography purified via peptide column.

Immunogen: LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2. The immunogen is located within the last 50 amino acids of LZTR2.

Isotype: IgG

Application Details

Application Notes: LZTR2 antibody can be used for detection of LZTR2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LZTR2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LZTR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SEC16B

Target: SEC16B (SEC16 Homolog B (SEC16B))

Alternative Name: LZTR2 (SEC16B Products)

Synonyms: LZTR2 antibody, PGPR-p117 antibody, RGPR antibody, SEC16S antibody, Lztr2 antibody, Rgpr antibody, Rgpr-p117 antibody, RGPR-p117 antibody, SEC16 homolog B, endoplasmic reticulum export factor antibody, SEC16 homolog B (S. cerevisiae) antibody, SEC16B antibody, sec16b antibody, Sec16b antibody

Background: LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.

Gene ID: 89866

NCBI Accession: NP_149118

UniProt: Q96JE7