ZC3H12A antibody (AA 330-380)

Catalog No. ABIN6991306

Product Details anti-ZC3H12A Antibody

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Binding Specificity: AA 330-380

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZC3H12A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: This ZC3H12A antibody is predicted to have no cross-reactivity to other members of the ZC3H12 protein family.

Purification: ZC3H12A Antibody is affinity chromatography purified via peptide column.

Immunogen: ZC3H12A antibody was raised against a 17 amino acid synthetic peptide near the center of human ZC3H12A. The immunogen is located within amino acids 330 - 380 of ZC3H12A.

Isotype: IgG

Application Details

Application Notes: ZC3H12A antibody can be used for detection of ZC3H12A by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZC3H12A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ZC3H12A

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Alternative Name: ZC3H12A (ZC3H12A Products)

Synonyms: CGA antibody, MCPIP antibody, MCPIP1 antibody, RP3-423B22.1 antibody, dJ423B22.1 antibody, BC036563 antibody, Mcpip1 antibody, RGD1306776 antibody, chromogranin A antibody, zinc finger CCCH-type containing 12A antibody, zinc finger CCCH type containing 12A antibody, CHGA antibody, ZC3H12A antibody, Zc3h12a antibody

Background: ZC3H12A Antibody: ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPgamma, demonstrating the complex roles ZC3H12A plays.

Molecular Weight: Predicted: 66 kDa

Observed: 6 kDa

Gene ID: 80149

NCBI Accession: NP_079355

UniProt: Q5D1E8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation