SLC39A6 antibody (AA 430-480)

Catalog No. ABIN6991455

Product Details anti-SLC39A6 Antibody

Target: SLC39A6 (Solute Carrier Family 39 (Zinc Transporter), Member 6 (SLC39A6))

Binding Specificity: AA 430-480

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: ZIP6 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZIP6 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP6. The immunogen is located within amino acids 430 - 480 of ZIP6.

Isotype: IgG

Application Details

Application Notes: ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZIP6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZIP6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC39A6

Target: SLC39A6 (Solute Carrier Family 39 (Zinc Transporter), Member 6 (SLC39A6))

Alternative Name: ZIP6 (SLC39A6 Products)

Synonyms: liv1 antibody, wu:fc25a09 antibody, ZIP6 antibody, Ermelin antibody, LIV-1 antibody, solute carrier family 39 (zinc transporter), member 6 antibody, solute carrier family 39 member 6 antibody, solute carrier family 39 (metal ion transporter), member 6 antibody, slc39a6 antibody, SLC39A6 antibody, Slc39a6 antibody

Background: ZIP6 Antibody: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line, down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.

Gene ID: 25800

NCBI Accession: NP_001092876

UniProt: Q13433

Pathways: Transition Metal Ion Homeostasis