IRF2BP2 antibody (C-Term)

Catalog No. ABIN6991645

Product Details anti-IRF2BP2 Antibody

Target: IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2))

Binding Specificity: AA 440-490, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF2BP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Specificity: At least two isoforms of IRF2BP2 are known to exist, this antibody will detect both. This antibody is predicted to not cross-react with any FOXD4 protein family members.

Purification: IRF2BP2 Antibody is affinity chromatography purified via peptide column.

Immunogen: IRF2BP2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human IRF2BP2. The immunogen is located within amino acids 440 - 490 of IRF2BP2.

Isotype: IgG

Application Details

Application Notes: IRF2BP2 antibody can be used for detection of IRF2BP2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IRF2BP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IRF2BP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IRF2BP2

Target: IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2))

Alternative Name: IRF2BP2 (IRF2BP2 Products)

Synonyms: E130305N23Rik antibody, IRF-2BP2 antibody, 5n852 antibody, irf2bp2-A antibody, IRF2BP2 antibody, fj35c12 antibody, irf2bp2b antibody, wu:fj35c12 antibody, zgc:56251 antibody, IRF-2-binding protein 2-B antibody, IRF-2BP2-B antibody, irf2bp2 antibody, irf2bp2a antibody, wu:fa12b04 antibody, wu:fb73g01 antibody, zgc:63864 antibody, interferon regulatory factor 2 binding protein 2 antibody, interferon regulatory factor 2 binding protein 2 L homeolog antibody, interferon regulatory factor 2 binding protein 2a antibody, interferon regulatory factor 2 binding protein 2b antibody, Irf2bp2 antibody, IRF2BP2 antibody, irf2bp2.L antibody, irf2bp2a antibody, irf2bp2b antibody

Background: IRF2BP2 Antibody: IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2). IRF2BP2 is a direct target gene of p53 and is involved in cell survival during the p53 stress response, able to impede the p53-mediated transactivation of p21 and Bax. IRF2BP2 is also a co-factor of VGLL4 and is required to induce the expression of vascular endothelial growth factor A (VEGF-A) in muscle. It is normally found in the nucleus of skeletal muscle and cardiac cells, but can be found in the cytoplasm during skeletal muscle differentiation.

Gene ID: 359948

NCBI Accession: NP_892017

UniProt: Q7Z5L9