CRIM1 antibody (C-Term)

Catalog No. ABIN6991727

Product Details anti-CRIM1 Antibody

Target: CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) (CRIM1))

Binding Specificity: AA 910-960, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRIM1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Specificity: CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.

Purification: CRIM1 Antibody is affinity chromatography purified via peptide column.

Immunogen: CRIM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Crim1. The immunogen is located within amino acids 910 - 960 of CRIM1.

Isotype: IgG

Application Details

Application Notes: CRIM1 antibody can be used for detection of Crim1 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRIM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CRIM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CRIM1

Target: CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) (CRIM1))

Alternative Name: CRIM1 (CRIM1 Products)

Synonyms: CRIM1 antibody, AU015004 antibody, wu:fc29f08 antibody, CRIM-1 antibody, S52 antibody, cysteine rich transmembrane BMP regulator 1 antibody, cysteine rich transmembrane BMP regulator 1 (chordin like) antibody, cysteine rich transmembrane BMP regulator 1 (chordin-like) antibody, CRIM1 antibody, Crim1 antibody, crim1 antibody

Background: CRIM1 Antibody: CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.

Gene ID: 51232

NCBI Accession: NP_057525

UniProt: Q9NZV1

Pathways: Growth Factor Binding