LAMTOR1 antibody (N-Term)

Catalog No. ABIN6991973

Product Details anti-LAMTOR1 Antibody

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMTOR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: LAMTOR1 antibody is human, mouse and rat specific. LAMTOR1 antibody is predicted to not cross-react with other LAMTOR family proteins.

Purification: LAMTOR1 antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal LAMTOR1 antibody was raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1 . The immunogen is located within the first 50 amino acids of LAMTOR1.

Isotype: IgG

Application Details

Application Notes: LAMTOR1 antibody can be used for detection of LAMTOR1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LAMTOR1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LAMTOR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for LAMTOR1

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Alternative Name: LAMTOR1 (LAMTOR1 Products)

Synonyms: C11orf59 antibody, PDRO antibody, Ragulator1 antibody, p18 antibody, p27RF-Rho antibody, 2400001E08Rik antibody, Pdro antibody, C15H11orf59 antibody, c11orf59 antibody, flj20625 antibody, p27rf-rho antibody, pdro antibody, ragulator1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antibody, LAMTOR1 antibody, Lamtor1 antibody, lamtor1.S antibody

Background: LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1). The mTORC1 kinase complex is a critical component in the regulation of cell growth (2). As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3). LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4).

Molecular Weight: Predicted: 18 kDa

Observed: 18 kDa

Gene ID: 55004

NCBI Accession: NP_060377

UniProt: Q6IAA8