TRF2 antibody (N-Term)

Catalog No. ABIN6991982

Product Details anti-TRF2 Antibody

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: TERF2 antibody is human specific.

Purification: TERF2 antibody is affinity chromatography purified via peptide column.

Immunogen: TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.

Isotype: IgG

Application Details

Application Notes: TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TERF2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TERF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TRF2

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Alternative Name: TERF2 (TERF2 Products)

Synonyms: TERF2 antibody, TRBF2 antibody, TRF2 antibody, trf2 antibody, telomeric repeat binding factor 2 antibody, telomeric repeat binding factor 2 L homeolog antibody, TERF2 antibody, Terf2 antibody, terf2.L antibody

Background: The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).

Molecular Weight: Predicted: 60 kDa

Observed: 69 kDa

Gene ID: 7014

NCBI Accession: NP_005643

UniProt: Q15554

Pathways: Cell Division Cycle, Telomere Maintenance