SLC1A7 antibody (C-Term)

Catalog No. ABIN6992100

Product Details anti-SLC1A7 Antibody

Target: SLC1A7 (Solute Carrier Family 1 (Glutamate Transporter), Member 7 (SLC1A7))

Binding Specificity: AA 460-510, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC1A7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.

Purification: SLC1A7 antibody is affinity chromatography purified via peptide column.

Immunogen: SLC1A7 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLC1A7. The immunogen is located within amino acids 460 - 510 of SLC1A7.

Isotype: IgG

Application Details

Application Notes: SLC1A7 antibody can be used for detection of SLC1A7 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SLC1A7 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SLC1A7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SLC1A7

Target: SLC1A7 (Solute Carrier Family 1 (Glutamate Transporter), Member 7 (SLC1A7))

Alternative Name: SLC1A7 (SLC1A7 Products)

Synonyms: SLC1A7 antibody, si:ch211-284b7.1 antibody, slc1a7 antibody, A930031E15Rik antibody, Eaat5 antibody, AAAT antibody, EAAT5 antibody, solute carrier family 1 member 7 antibody, solute carrier family 1 (glutamate transporter), member 7a antibody, solute carrier family 1 (glutamate transporter), member 7 antibody, SLC1A7 antibody, slc1a7a antibody, Slc1a7 antibody

Background: The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1). More recent evidence indicates that is it widely expressed in peripheral tissues, also (2). Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3). In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4).

Molecular Weight: Predicted: 17, 52, 62, 68 kDa

Observed: 52 kDa

Gene ID: 6512

NCBI Accession: NP_001274524

UniProt: O00341

Pathways: Dicarboxylic Acid Transport