PACS2 antibody (AA 330-380)

Catalog No. ABIN6992140

Product Details anti-PACS2 Antibody

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Binding Specificity: AA 330-380

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist, this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.

Purification: PACS2 antibody is affinity chromatography purified via peptide column.

Immunogen: PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2. The immunogen is located within amino acids 330 - 380 of PACS2.

Isotype: IgG

Application Details

Application Notes: PACS2 antibody can be used for detection of PACS2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PACS2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PACS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for PACS2

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Alternative Name: PACS2 (PACS2 Products)

Synonyms: PACS-2 antibody, PACS1L antibody, 6720425G15Rik antibody, AW208651 antibody, AW489976 antibody, E230011J22 antibody, Pacs1l antibody, mKIAA0602 antibody, phosphofurin acidic cluster sorting protein 2 antibody, PACS2 antibody, Pacs2 antibody

Background: PACS2 (phosphofurin acidic cluster sorting protein-2), PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1,2). It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2,). PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5).

Molecular Weight: Predicted: 98 kDa

Observed: 95 kDa

Gene ID: 23241

NCBI Accession: NP_056012

UniProt: Q86VP3